Duodenal lipid-induced symptom generation in gastroesophageal reflux disease: role of apolipoprotein A-IV and cholecystokinin
Neurogastroenterology & Motility,  Clinical Article

van Boxel OS et al. – The results suggest excessive duodenal lipid–induced release of apolipoprotein A–IV (apoA–IV) and cholecystokinin (CCK) in gastro–esophageal reflux disease (GERD). The authors postulate that the resulting heightened activation of duodenal vagal afferents may underlie central sensitization, thereby increasing the perception of reflux events.

Methods
  • Ten GERD patients and 10 healthy volunteers (HV) underwent duodenal perfusion with Intralipid 20%, 2 kcal min-1, for 60 min.
  • Symptoms were scored, blood samples collected every 15 min during lipid perfusion and 15 min after discontinuation when duodenal biopsies were taken.
  • Plasma and mucosal concentrations of apoA-IV and CCK and transcript levels of 21 genes implicated in lipid absorption, differentially expressed under fasting conditions, were quantified.

Results
  • Heartburn (P = 0.003), abdominal discomfort (P = 0.037) and nausea (P = 0.008) only increased significantly during lipid infusion in GERD patients.
  • Following lipid infusion mean mucosal apoA-IV concentration was lower in GERD patients compared with HV (P = 0.023), whereas plasma concentration tended to be elevated (P = 0.068).
  • Mean mucosal CCK concentration was also lower in GERD patients (P = 0.009).
  • Two genes, HIBADH and JTB, were upregulated in GERD patients (P = 0.008 and P = 0.038, respectively).

Please login or register to follow this author.
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Allergy/Immunology

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Allergy/Immunology Articles

1 Disagreement between skin prick test and specific IgE in young children Allergy, September 22, 2014    Clinical Article

2 Antibacterial ally Harvard Medical School News, November 17, 2014

3 The predictive value of allergen skin prick tests and IgE tests at pre-school age: the PACT study Pediatric Allergy and Immunology, October 16, 2014    Clinical Article

4 Omalizumab in children Pediatric Drugs, November 26, 2014    Clinical Article

5 The use of single versus multiple antigens in specific allergen immunotherapy for allergic rhinitis: Review of the evidence Current Opinion in Allergy and Clinical Immunology, January 9, 2014    Evidence Based Medicine    Review Article

6 Airborne contact dermatitis: Common causes in the USA International Journal of Dermatology, July 10, 2014    Review Article

7 Scripps Research Institute scientists reveal weak spots in Ebola's defenses Scripps Research Institute News, November 20, 2014

8 EV71 vaccine, an invaluable gift for children Full Text Clinical & Translational Immunology, November 5, 2014    Free full text    Review Article

9 Protective effect of a low single dose inhaled steroid against exercise induced bronchoconstriction Pediatric Pulmonology, November 24, 2014    Clinical Article

10 Effect of prasugrel in patients with asthma: results of PRINA,a randomized, double-blind, placebo-controlled, cross-over study Journal of Thrombosis and Haemostasis, November 25, 2014

11 Responsiveness to inhaled corticosteroid treatment in patients with asthma-chronic obstructive pulmonary disease overlap syndrome Annals of Allergy, Asthma, and Immunology, November 3, 2014    Clinical Article

12 Standalone balloon dilation versus sinus surgery for chronic rhinosinusitis: A prospective, multicenter, randomized, controlled trial with 1-year follow-up The American Journal of Rhinology & Allergy, August 1, 2014    Clinical Article

13 A dose-ranging study of the bronchodilator effects of abediterol (LAS100977), a long-acting beta2-adrenergic agonist, in asthma; a Phase II, randomized study Full Text BMC Pulmonary Medicine, November 21, 2014    Free full text    Clinical Article

14 You might be allergic to penicillin. Then again, you might not American College of Allergy, Asthma and Immunology News, November 10, 2014

15 The diagnosis and management of food allergy and food intolerances Alimentary Pharmacology and Therapeutics, October 30, 2014    Review Article

16 25-hydroxyvitamin d3-deficiency enhances oxidative stress and corticosteroid resistance in severe asthma exacerbation PLOS ONE, November 14, 2014    Clinical Article

17 Fluticasone furoate/vilanterol 200/25mcg in Asian asthma patients: A randomized trial Respiratory Medicine, November 7, 2014    Clinical Article

18 Long-acting anticholinergic agents in patients with uncontrolled asthma: a systematic review and meta-analysis The International Journal of Tuberculosis and Lung Disease, November 21, 2014    Evidence Based Medicine    Review Article

19 New gluten-free ingredient may cause allergic reaction Kansas State University News, August 26, 2014

20 Angiotensin converting enzyme inhibitor-related angioedema: Onset, presentation, and management Annals of Otology, Rhinology & Laryngology, August 11, 2014    Clinical Article

Indexed Journals in Allergy/Immunology: Allergy, Clinical Immunology, Annals of Allergy, Asthma, and Immunologymore