Statin use in patients with asthma a nationwide population-based study
European Journal of Clinical Investigation, 04/12/2011
Huang CC et al. – Statin use is associated with reduced hospitalization for asthma attack in patients with asthma, suggesting possible applications of statin in patients with asthma.Methods
- The authors conducted a nationwide population–based study to investigate the possible influence of statin use on patients with asthma using the Taiwan National Health Insurance Database.
- A total of 3965 patients with asthma (mean age 60.69 ± 0.39 years, male 41.3%) who received statins after asthma diagnosis were identified from the 1 000 000 sampling cohort data set between January 2000 and December 2007.
- Another 7843 patients with asthma who were matched for age, gender and medication for asthma treatment but did not use statin were enrolled as the control group.
- The patients with statin use had more hypertension (P < 0.001), diabetes mellitus (P < 0.001), coronary artery disease (P < 0.001), dysrhythmia (P = 0.001) and chronic kidney disease (P < 0.001) than patients without statin use.
- Till the end of 2007, there were 974 patients who were hospitalized because of asthma.
- After multivariate analysis, only increasing age (hazard ratio, 1.02; 95% confidence interval, 1.02–1.03, P < 0.001) and statin use (hazard ratio, 0.82; 95% confidence interval, 0.71–0.95, P = 0.006) were independently associated with the decreased risk of hospitalization for asthma.