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Regulation of major histocompatibility complex class II gene expression, genetic variation and disease
Genes and Immunity, 11/10/09
Handunnetthi L et al. – Although much emphasis has been placed on cis–regulatory elements, the authors also examine the role of more distant enhancer elements together with the evidence of dynamic inter– and intra–chromosomal interactions and epigenetic processes. The role of genetic variation in such mechanisms may hold profound implications for susceptibility to common disease.
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