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Expansion of Functionally Skewed CD56-Negative NK Cells in Chronic Hepatitis C Virus Infection: Correlation with Outcome of Pegylated IFN-alpha and Ribavirin Treatment
Journal of Immunology, 11/10/09

Gonzalez VD et al. – In patients with CD56– NK cells in the range of healthy subjects, 80% reached a sustained virological response to treatment, whereas only 25% of patients with levels clearly above those in healthy subjects experienced a sustained virological response. Thus, chronic hepatitis C virus infection is associated with an expansion of CD56– NK cells functionally skewed toward MIP–1[beta] production only.

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