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Canonica GW et al. – Treating overt allergy symptoms as well as this underlying inflammatory state requires agents that have well–established clinical efficacy, convenient administration, potent anti–inflammatory effects and proven long–term safety, so that long–term continuous administration is feasible. Of the three major classes of commonly used allergic rhinitis medications – intranasal corticosteroids, anti–histamines, and anti–leukotrienes – intranasal corticosteroids appear to represent the most reasonable therapeutic option in patients who would benefit from continuous inhibition of persistent inflammation.


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