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See Latest ArticlesTherapeutic Drug Monitoring of Lopinavir in Human Immunodeficiency Virus-Infected Children Receiving Adult Tablets: Therapeutic Drug Monitoring of Lopinavir Tablets Given To Children
The Pediatric Infectious Disease Journal, 10/29/09
Puthanakit T et al. – Because of the lack of a lopinavir/ritonavir (LPV/r) pediatric formulation, 54 HIV–infected children were given generic LPV/r adult tablets. Of 54 children, 21 took cut pills to get the appropriate dose. The median (interquartile range) LPV trough serum concentration (Ctrough) was 6.7 (5.0–9.9) mg/L. All the children had Ctrough >1.0 mg/L and 96% had values >4.0 mg/L. LPV/r adult tablets can be used in children when it is necessary.
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