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See Latest ArticlesSubtilase cytotoxin cleaves newly synthesized BiP and blocks antibody secretion in B lymphocytes
Journal of Experimental Medicine, 11/04/09
Hu CCA et al. – Although SubAB also causes BiP cleavage in HepG2 hepatoma cells, (glyco)protein secretion continues unabated in SubAB–exposed HepG2 cells. This specific block in antibody secretion is a novel means of immune evasion for STEC. The differential cleavage of newly synthesized versus "aged" BiP by SubAB in the ER provides insight into the architecture of the ER compartments involved.
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