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Immunization via the anal mucosa and adjacent skin to protect against respiratory virus infections and allergic rhinitis: A hypothesis
Medical Hypotheses, 10/30/09
Spencer JL – Although other respiratory viruses are unlikely to survive passage through the intestinal tract, rhinovirus has on rare occasion been detected in stool specimens, suggesting the possibility of an infection at the terminal end of the digestive tract. Respiratory syncytial viruses and influenza viruses are amenable to modification by reverse genetics and other techniques and it is expected that natural or modified viruses applied to the anal region could serve to immunize the respiratory tract.
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