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Thymocyte deletion can bias Treg formation toward low-abundance self-peptide
European Journal of Immunology, 10/26/09
Picca CC et al. – The findings provide evidence that Foxp3+ Treg can develop among members of a cohort of autoreactive thymocytes that have evaded deletion by a self–peptide, and that deletion and Treg formation can act together to bias the Treg repertoire toward low–abundance self–peptide(s).
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