Allergy/Imm Medical News about adiponectin

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A rosiglitazone-induced increase in adiponectin does not improve glucose metabolism in HIV-infected patients with overt lipoatrophy
Endocrinology and Metabolism, 10/30/09

Blumer RME et al. – HIV–infected patients on antiretroviral therapy frequently develop changes in body fat distribution and disturbances in glucose metabolism, associated with reduced adiponectin levels. Because adiponectin, principally the high–molecular–weight (HMW) form, has insulin–sensitizing properties, the authors investigated the effects of an increase in adiponectin on glucose metabolism in HIV–lipodystrophy. Acknowledging the limited statistical power of the small study, these findings, if confirmed by larger studies, could question the importance of adiponectin in regulating glucose metabolism in HIV–lipodystrophy.

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Adiponectin may contribute to synovitis and joint destruction in rheumatoid arthritis by stimulating vascular endothelial growth factor, matrix metalloproteinase-1, and matrix metalloproteinase-13 expression in fibroblast-like synoviocytes more than proinflammatory mediators
Arthritis Research & Therapy, 11/11/09 Relevance Score: 94%

Adiponectin in insulin resistance: lessons from translational research
American Journal of Clinical Nutrition, 11/13/09 Relevance Score: 92%

Enhanced insulin sensitivity after acute exercise is not associated with changes in high-molecular weight adiponectin concentration in plasma
European Journal of Endocrinology, 11/05/09 Relevance Score: 92%

Menopause impacts the relation of plasma adiponectin levels with the metabolic syndrome
Journal of Internal Medicine, 11/17/09 Relevance Score: 90%

Circulating Adiponectin: Associations with Risk Factors and the Reynolds Risk Score in Women without Prior Major Cardiovascular Events
Cardiology, 10/30/09 Relevance Score: 90%