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FCRL3, an Autoimmune Susceptibility Gene, Has Inhibitory Potential on B-Cell Receptor-Mediated Signaling
Journal of Immunology, 10/23/09
Kochi Y et al. – The results, together with previous genetic data, suggest that augmented inhibition of BCR–mediated signaling by FCRL3 with the disease–risk genotype alter the activation threshold and promote tolerance breakdown in B cells.
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