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The Adaptor Protein Shc Plays a Key Role during Early B Cell Development1
Journal of Immunology, 10/23/09
Giles AJ et al. – The data demonstrate a critical role for Shc in early B lymphopoiesis with a requirement in early B cell survival. In addition, the authors also identify Shc as a required player in signaling downstream of the IL–7R in early B cells.
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