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Guiso N – The use of pertussis whole–cell vaccines in infants and toddlers led to decreased circulation of the bacterium in the child population and a marked decrease in the incidence of the disease. However, vaccine does not result in life–long immunity; indeed, the circulation of the bacterium has not been controlled in the adult population. Universal adult booster immunization is now possible using pertussis acellular vaccines, which target–and are thus likely to control–the virulence of this bacterium.


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