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Sordi V – Although the mechanisms by which MSCs are recruited to tissues and cross the endothelial cell layer are not yet fully understood, it is probable that chemokines and their receptors are involved, as they are important factors known to control cell migration. The CXCR4–CXCL12 and CX3CR1–CX3CL1 axes, for instance, drive the crosstalk between MSCs and pancreatic islets.


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