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See Latest ArticlesEvidence that cathelicidin peptide LL-37 may act as a functional ligand for CXCR2 on human neutrophils
European Journal of Immunology, 10/26/09
Zhang Z et al. – Among all ligands tested (ATP, BzATP, WKYMVm, CXCL1, and LL–37), only LL–37 stimulated migration of monocytes (CXCR2+ and FPR2+) and migration was inhibited by the CXCR2 inhibitor SB225002. Moreover, CXCR2 but not CXCR1 was internalized in LL–37–treated neutrophils. Thus, the data provide evidence that LL–37 may act as a functional ligand for CXCR2 on human neutrophils.
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