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A Recurrent Network Involving the Transcription Factors PU.1 and Gfi1 Orchestrates Innate and Adaptive Immune Cell Fates
Immunity, 10/27/09
Spooner CJ et al. – The results reveal that a core transcriptional regulatory network used for directing cell fate choice in the innate immune system has been co–opted by Ikaros to orchestrate B lymphocyte generation. These findings have important implications for the evolution of the adaptive immune system.
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