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Alloantigen-specific de novo-induced Foxp3+ Treg revert in vivo and do not protect from experimental GVHD
European Journal of Immunology, 11/06/09
Koenecke C et al. – The authors suggest that therapeutic approaches to treat GVHD should rely on nTreg, whereas the use of de novo alloantigen–induced iTreg should be handled with caution since the stability of the regulatory phenotype of the iTreg could be of major concern.
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