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See Latest ArticlesDefective eosinophil chemotaxis to eotaxin in a patient with chronic lower baseline CD4+ T-lymphocytes and elevated CD8+ T cells
International Journal of General Medicine, 10/12/09
El–Shazly AE et al. – Idiopathic selective CD4+ lower baseline cell count and an increase in CD8+ cells is an unusual immune defect. Whether this is a true variant of idiopathic CD4+ T lymphocytopenia (ICL) or a sequelae to recurrent infections is not clear...Taken collectively, these preliminary results may indicate a novel role for IL–7 in enhancing the CCR3 expression and function in patients of this syndrome and highlights the novel role of IL–10 in inducing a significant increase in CD4+–expressing lymphocytes from the patient when compared to controls.
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Inhibition of HIV-1 integrase nuclear import and replication by a peptide bearing integrase putative nuclear localization signal
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