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HLA diversity: Detection and impact on unrelated hematopoietic stem cell · donor characterization and selection
International Journal of Hematology, 10/07/09
Hurley CK – The links between alleles and serologic specificities remain unclear in many cases and complicate the design of computer algorithms used to match patients and donors. Finally, since few patients will find donors who are allele matched for all HLA loci, studies are underway to understand which of the HLA loci are most critical to match and to define rules of permissive mismatching to achieve an acceptable outcome.
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