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Prolonging microtubule dysruption enhances the immunogenicity of chronic lymphocytic leukaemia cells
Clinical and Experimental Immunology, 10/05/09
Shaha SP et al. – This phenotype was similar to the result of activating CLL cells through Toll–like receptors (TLRs), which communicate 'danger' signals from infectious pathogens. Use of PKC agonists and microtubule inhibitors to mimic TLR–signalling, and increase the immunogenicity of CLL cells, has implications for the design of chemo–immunotherapeutic strategies.
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