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Antitumor Immunity Can Be Uncoupled from Autoimmunity following Heat Shock Protein 70–Mediated Inflammatory Killing of Normal Pancreas
Cancer Research, 10/06/09

Kottke T et al. – The data indicate that profound differences exist between the immunoprotective mechanisms in place between different tissues (pancreas and prostate) in their response to pathogen–like damage. Moreover, they also show that, although multiple layers of immunologic safeguards are in place to prevent the development of severe autoimmune consequences in the pancreas (in contrast to the prostate), tumor rejection responses can still be decoupled from pathologic autoimmune responses in vivo, which may provide novel insights into the immunotherapeutic treatment of pancreatic cancer.

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CD46-induced human Treg enhance B-cell responses

Platelet-Derived Transforming Growth Factor-beta Down-Regulates NKG2D Thereby Inhibiting Natural Killer Cell Antitumor Reactivity
Cancer Research, 10/06/09 Relevance Score: 66%

Tumor Apoptotic Bodies Inhibit CTL Responses and Antitumor Immunity via Membrane-Bound Transforming Growth Factor-beta1 Inducing CD8+ T-Cell Anergy and CD4+ Tr1 Cell Responses
Cancer Research, 10/06/09 Relevance Score: 66%

Partial CD4 Depletion Reduces Regulatory T Cells Induced by Multiple Vaccinations and Restores Therapeutic Efficacy
Clinical Cancer Research, 11/16/09 Relevance Score: 64%

Anticancer Chemotherapy Inhibits MHC Class I–Related Chain A Ectodomain Shedding by Downregulating ADAM10 Expression in Hepatocellular Carcinoma
Cancer Research, 10/21/09 Relevance Score: 64%

EBV-Induced Human CD8+ NKT Cells Suppress Tumorigenesis by EBV-Associated Malignancies
Cancer Research, 10/21/09 Relevance Score: 64%