Allergy/Imm Medical News about Autoimmune Diseases Pancreatitis

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Autoimmune pancreatitis: A mimic of pancreatic cancer
Cleveland Clinic Journal of Medicine, 10/16/09

Law R et al. – Autoimmune pancreatitis is an idiopathic inflammatory disease that produces pancreatic masses and ductal strictures. This benign disease resembles pancreatic carcinoma both clinically and radiographically. The diagnosis of autoimmune pancreatitis is challenging to make. However, accurate and timely diagnosis may preempt the misdiagnosis of cancer and decrease the number of unnecessary pancreatic resections.

Hallmark features of autoimmune pancreatitis include an elevated serum immunoglobulin G4 level, focal or diffuse pancreatic enlargement on imaging, and dense lymphoplasmacytic infiltrates on histologic study.
The disease can be associated with extrapancreatic manifestations, including sclerosing cholangitis, sialadenitis and retroperitoneal fibrosis.
Autoimmune pancreatitis responds dramatically to corticosteroid treatment.

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Etiology of chronic pancreatitis: Has it changed in the last decade
World Journal of Gastroenterology, 10/19/09 Relevance Score: 81%

Autoimmune pancreatitis: A challenging diagnostic puzzle for clinicians
Digestive and Liver Diseases, 10/07/09 Relevance Score: 81%

Diabetes associated with autoimmune pancreatitis: new insights into the mechanism of beta-cell dysfunction
Expert Review of Endocrinology & Metabolism, 11/17/09 Relevance Score: 80%

Frequent and Significant K-ras Mutation in the Pancreas, the Bile Duct, and the Gallbladder in Autoimmune Pancreatitis
Pancreas, 10/23/09 Relevance Score: 80%

IgG4 Related Sclerosing Disease With Multiple Organ Involvements and Response to Corticosteroid Treatment
Journal of Clinical Rheumatology (JCR), 10/14/09 Relevance Score: 80%