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Thymic epithelial cells: the multi-tasking framework of the T cell cradle
Trends in Immunology, 10/05/09
Alves NL et al. – The authors propose that crucial instructive signals delivered by developing thymocytes negatively regulate functional attributes of immature TECs (including the expression of Delta–like 4 (DLL4) and interleukin–7 (IL–7)) that are required during early stages of thymopoiesis, while promoting the diversification of more mature TEC subsets. Thus, the division of labour among TECs may be coordinated directly by local cellular feedback mechanisms operating within distinct thymic niches.
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