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See Latest ArticlesEstrone/17[beta]-estradiol conversion to, and tumor necrosis factor inhibition by, estrogen metabolites in synovial cells of patients with rheumatoid arthritis and patients with osteoarthritis
Arthritis & Rheumatism, 10/01/09
Schmidt M et al. – Our findings indicate that precursor estrogens are converted to proinflammatory metabolites, particularly in RA synovial cells. RA synovial cells mainly produce the proproliferative 16OH-estrone, which, in addition to 16&alphaOH-17&beta-estradiol, is one of the only 2 estrogens studied that does not inhibit TNF secretion. A preponderance of 16&alpha-hydroxylated estrogens is an unfavorable sign in synovial inflammation.
Methods- serum levels of estrone, estrone sulfate, and estrone sulfate membrane transporters, intracellular interconversion of estrone and 17-estradiol, and conversion of estrone/17&beta-estradiol to various estrogen metabolites in RA and OA synovial cells
- Serum levels of estrone sulfate similar in healthy controls and RA
- Estrone sulfate transporters were present in synovial tissue. Interconversion of estrone and 17&beta-estradiol and the expression of converting enzymes of the cytochrome P450 family were similar in RA and OA cells
- Using estrone and 17&beta-estradiol as substrates, RA and OA synovial cells produced 16&alphaOH -, 4-, and 2-hydroxylated estrogens and their 4- and 2-methylation products
- The levels of 16-hydroxylated estrone/17-estradiol (16OH-estrone/16OH-17-estradiol) were higher than the levels of all other estrogen metabolites
- RA synovial cells produced more 16OH-estrone than did OA synovial cells
- 16OH estrogens did not inhibit TNF secretion; all other estrogen metabolites had marked inhibitory effects
Today in Rheumatology...keeping you current
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Elevated Circulating and Synovial Fluid Endoglin Are Associated with Primary Knee Osteoarthritis Severity
Archives of Medical Research, 12/20/09
Anticyclic Citrullinated Peptide Antibody-Positive Paraneoplastic Polyarthritis in a Patient With Metastatic Pancreatic Cancer
The American Journal of the Medical Sciences, 12/18/09
Lateral back pain identifies prevalent vertebral fractures in post-menopausal women: Cross-sectional analysis of a primary care-based cohort
Rheumatology, 12/18/09
Today in Basic Science/Genetics...keeping you current
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Mutations in the perforin gene can be linked to macrophage activation syndrome in patients with systemic onset juvenile idiopathic arthritis
Rheumatology, 12/20/09
The 'RASor's' edge: Ras proteins and matrix destruction in arthritis
Arthritis Research & Therapy, 12/19/09
Unresponsiveness to colchicine therapy in patients with familial Mediterranean fever homozygous for the M694V mutation
Journal of Rheumatology, 12/17/09
Today in Osteoarthritis...keeping you current
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Phytalgic(R), a food supplement, vs placebo in patients with osteoarthritis of the knee or hip: a randomised double-blind placebo-controlled clinical trial
Arthritis Research & Therapy, 12/19/09
The effects of electrical stimulation combined with continuous passive motion versus isometric exercise on symptoms, functional capacity, quality of life and balance in knee osteoarthritis: Randomized clinical trial
Rheumatology International, 12/18/09
Randomized double-blind placebo-controlled trial on the potential modes of action of sheaflex70tm in osteoarthritis
Phytotherapy Research, 12/15/09
Today in Rheumatoid Arthritis...keeping you current
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Immunoglobulin G galactosylation and sialylation are associated with pregnancy-induced improvement of rheumatoid arthritis and the postpartum flare: results from a large prospective cohort study
Arthritis Research & Therapy, 12/19/09
Update on the genetic risk factors for rheumatoid arthritis
Expert Review of Clinical Immunology, 12/18/09
The diagnostic utilities of anti-agalactosyl IgG antibodies, anti-cyclic citrullinated peptide antibodies, and rheumatoid factors in rheumatoid arthritis
Rheumatology International, 12/18/09
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