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See Latest ArticlesSelf-class I MHC molecules support survival of naive CD8 T cells, but depress their functional sensitivity through regulation of CD8 expression levels
Journal of Experimental Medicine, 10/06/09
Takada K et al. – The authors found that this improved sensitivity was a consequence of up–regulated CD8 levels, which was mediated through a transcriptional mechanism. Hence, the data suggest that, in a nonlymphopenic setting, self–class I MHC molecules support CD8 T cell survival, but that these interactions also attenuate naive T cell sensitivity by dynamic tuning of CD8 levels.
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