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Obase Y et al. – Inhaled budesonide normalized the MMP–8/TIMP–1 ratio in asthmatic children by upregulation of TIMP–1 production and downregulation of MMP–8 production by airway macrophages. This change may be a biochemical marker of an effect on airway inflammation and possibly of an ongoing remodeling process that should be further investigated using biopsy specimens.

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