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See Latest ArticlesEsterases and autoimmunity: the sialic acid acetylesterase pathway and the regulation of peripheral B cell tolerance
Trends in Immunology, 10/08/09
Pillai S et al. – Another important and distinct mechanism of B cell tolerance involves the repression of antigen receptor signaling rather than its induction, utilizes the Lyn Src–family kinase, the SHP–1 tyrosine phosphatase, inhibitory members of the Siglec family, and a carbohydrate–modifying enzyme that is capable of negatively regulating B cell receptor activation known as sialic acid acetylesterase.
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