Allergy/Imm Medical News about aspirin

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Modulation by aspirin of nuclear phospho–signal transducer and activator of transcription 6 expression: Possible role in therapeutic benefit associated with aspirin desensitization
Journal of Allergy and Clinical Immunology, 09/23/09

Steinke JW et al. – The LT receptor and synthase promoters have STAT6–binding sites that are engaged by IL–4–induced nuclear extracts and inhibited by aspirin. Assuming that normal monocytes behave like monocytes from patients with aspirin–exacerbated respiratory disease, inhibition of IL–4–STAT6 might explain a mechanism in aspirin desensitization daily treatment, resulting in downregulation of production and responsiveness to cysteinyl leukotrienes. This biologic activity of aspirin likely reflects COX inhibition because it was shared with ketorolac but not sodium salicylate.

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