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Lloyd AL et al. – The most significant colonization defect of the sisA sisB mutant in vivo was observed during independent challenge relative to wild–type CFT073, with attenuation of the mutant observed in the bladder and kidneys at 6 hpi. By 24 and 48 hpi, the [delta]sisA [delta]sisB mutant was no longer significantly attenuated in the bladder or kidneys, suggesting that the [delta]sisA and [delta]sisB genes may be important for suppressing the host immune response during the initial stages of infection.


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