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The inhibitory fciib receptor dampens tlr4-mediated immune responses and is selectively up-regulated on dendritic cells from rheumatoid arthritis patients with quiescent disease
Journal of Immunology, 09/28/09
Wenink MH et al. – Blocking FcgammaRIIb with specific Abs fully abrogated these effects demonstrating the full dependence on the inhibitory FcgammaRIIb in the induction of these phenomena. This TLR4–FcgammaRIIb interaction was shown to dependent on the PI3K and Akt pathway.
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Today in Rheumatic/Autoimmune...keeping you current
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Contribution of a haplotype in the HLA region to anti-cyclic citrullinated peptide antibody positivity in rheumatoid arthritis, independently of HLA-DRB1
Arthritis & Rheumatism, 12/10/09
Normal Regional Lymph Node Enrichment of Antigen-Specific Regulatory T Cells with Autoimmune Disease-Suppressive Capacity
Journal of Immunology, 12/10/09
Autoimmune Regulator Deficiency Results in Decreased Expression of CCR4 and CCR7 Ligands and in Delayed Migration of CD4+ Thymocytes
Journal of Immunology, 12/10/09
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