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Adding Omalizumab to the Therapy of Adolescents With Persistent Uncontrolled Moderate-Severe Allergic Asthma
Clinical Pediatrics, 09/18/09

Massanari M et al. – Omalizumab added to baseline therapy improves measures of asthma control in adolescents with persistent moderate–severe allergic asthma.

Exclusive Author Commentary
M. Massanari, 10/09/09

Achieving control of asthma is often difficult, particularly among adolescent patients with moderate-severe disease . Serum IgE plays an important role in the allergic asthma cascade. Addition of omalizumab, a humanized monoclonal anti-IgE antibody, to inhaled corticosteroids improves asthma control by reducing exacerbations and improving symptoms.

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Clinical importance of identifying immunoglobulin E-mediated disease in patients with Asthma
Clinical Cornerstone, 10/01/09 Relevance Score: 96%

Bone mineral density and fractures in older men with chronic obstructive pulmonary disease or asthma
Osteoporosis International, 10/13/09 Relevance Score: 95%

The Saudi Initiative for asthma
Annals of Thoracic Medicine, 10/13/09 Relevance Score: 95%

Consistently very poorly controlled asthma, as defined by the impairment domain of the Expert Panel Report 3 guidelines, increases risk for future severe asthma exacerbations in The Epidemiology and Natural History of Asthma: Outcomes and Treatment Regimens (TENOR) study
Journal of Allergy and Clinical Immunology, 10/09/09 Relevance Score: 95%

Identification of Asthma Phenotypes using Cluster Analysis in the Severe Asthma Research Program
American Journal of Respiratory and Critical Care Medicine, 11/09/09 Relevance Score: 94%