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Origin of the Lamina Propria Dendritic Cell Network
Immunity, 10/01/09
Bogunovic M et al. – CD103+CX3CR1? DCs but not CD103?CX3CR1+ DCs in the lamina propria constitutively expressed CCR7 and were the first DCs to transport pathogenic Salmonella from the intestinal tract to the mesenteric lymph nodes. Altogether, these results underline the diverse origin of the lamina propria DC network and identify mucosal DCs that arise from pre–DCs as key sentinels of the gut immune system.
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