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Small, Mobile Fc[epsilon]RI Receptor Aggregates Are Signaling Competent
Immunity, 10/01/09
Andrews NL et al. – The kinase inhibitor PP2 blocked secretion without affecting immobilization or internalization. They propose that immobility is a feature of highly crosslinked immunoreceptor aggregates and a trigger for receptor internalization, but is not required for tyrosine kinase activation leading to secretion.
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