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See Latest ArticlesThe Transcriptional Repressor Bcl-6 Directs T Follicular Helper Cell Lineage Commitment
Immunity, 10/01/09
Yu D et al. – Bcl–6 bound to the promoters of the Th1 and Th17 cell transcriptional regulators T–bet and RORgammat and repressed IFN–gamma and IL–17 production. Bcl–6 also repressed expression of many microRNAs (miRNAs) predicted to control the Tfh cell signature, including miR–17–92, which repressed CXCR5 expression. Thus, Bcl–6 positively directs Tfh cell differentiation, through combined repression of miRNAs and transcription factors.
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