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See Latest ArticlesRethinking the Pathogenesis of Asthma
Immunity, 09/18/09
Holgate ST et al. – Asthma research has focused primarily on allergic pathways on the basis that the majority of asthma is associated with atopy, the recruitment of the Th2–type T cell, the cytokines, and the chemokines that are released on exposure to allergens, and the IgE pathway. These factors act locally on a susceptible airway epithelium that is both structurally and functionally deficient. It may be worthwhile to focus on increasing the resilience of the airways to environmental insults in addition to improving strategies that modify adaptive immunity or suppress inflammation.
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