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The Interferon System and Vaccinia Virus Evasion Mechanisms
Journal of Interferon & Cytokine Research, 10/07/09
Perdiguero B et al. – This review analyzes current knowledge on the VACV genes encoding proteins acting as decoy receptors to block the activity of type I and type II IFNs, targeting cytokines and chemokines, and antagonizing intracellular signaling pathways (pattern recognition receptors [PRRs] signaling). The molecular dissection of how VACV prevents the IFN response is providing important insights on our understanding of antiviral action and immune surveillance.
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