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The Regulation of Type I Interferon Production by Paramyxoviruses
Journal of Interferon & Cytokine Research, 10/07/09
Goodbourn S et al. – The authors review the knowledge of the type I IFN–inducing signals (by so–called pathogen–associated molecular patterns, or PAMPs) produced during paramyxovirus infections, and discuss how paramyxoviruses limit the production of PAMPs and inhibit the cellular responses to PAMPs by interfering with the activities of the pattern recognition receptors (PRRs), mda–5, and RIG–I, as well as downstream components in the type I IFN induction cascades.
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