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Miyata M et al. – The findings suggest that TSLP is an important mediator of IL–13–driven allergic inflammation in the nasal mucosa. Taken together with the recent findings that IL–13 is a critical downstream element for TSLP–driven allergic inflammation, TSLP may function both upstream and downstream of IL–13, thus providing an additional rationale as to why TSLP plays such a central role in the development of allergic inflammation.


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