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See Latest ArticlesHuman subjects are protected from mast cell tryptase deficiency despite frequent inheritance of loss-of-function mutations
Journal of Allergy and Clinical Immunology, 09/18/09
Trivedi NN et al. – Tryptase deficiency alleles are common, causing the number of inherited active genes to range from a minimum of 2 to a maximum of 4, with major differences between populations in the proportion of individuals inheriting 2 versus 4 active alleles. Strong linkage of TPSAB1 and TPSB2 and pairing of deficiency alleles with functional alleles in observed haplotypes protect human subjects from “knockout” genomes and indeed from inheritance of fewer than 2 active alleles.
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Today in Basic Science/Genetics...keeping you current
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