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See Latest ArticlesA naturally occurring Rgg variant in serotype M3 Streptococcus pyogenes does not activate speB expression due to altered specificity of DNA binding
Infection and Immunity, 10/05/09
Kappeler KV et al. – In contrast to Rgg103S, Rgg103P does not bind to the speB promoter in gel–shift assays, which correlates with a lack of speB expression. Despite the inability to activate speB expression, Rgg103P retains the ability to bind to DNA upstream of norA, and to influence its expression. Overall, the studies illustrate how variation at the rgg locus may contribute to the phenotypic diversity of S. pyogenes.
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