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Corthay A – The classification of Treg cells as a separate lineage remains controversial because the ability to suppress is not an exclusive Treg property. Suppressive activities attributed to Treg cells may in reality, at least in some experimental settings, be exerted by conventional Th cell subsets, such as Th1, Th2, Th17 and T follicular (Tfh) cells. Recent reports have also demonstrated that Foxp3+ Treg cells may differentiate in vivo into conventional effector Th cells, with or without concomitant downregulation of Foxp3.

Exclusive Author Commentary
A Corthay, 10/05/09

This article is ”Online Open” and can be freely downloaded at the Scandinavian Journal of Immunology’s website: www3.interscience.wiley.com/journal/118494826/home.

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