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Gut-associated lymphoid tissue contains the molecular machinery to support T-cell-dependent and T-cell-independent class switch recombination
Mucosal Immunology, 09/10/09
Barone F et al. – No activation–induced cytidine deaminase (AID) expression (an absolute requirement for class switching) was detected in lamina propria by IHC or qRT–PCR. APRIL and its receptors were only observed alongside AID in GALT, showing that GALT contains the apparatus to support both T–independent and T–dependent routes to IgA CSR.
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Today in Gastrointestinal/Hepatic...keeping you current
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Cycling of gut mucosal CD4+ T cells decreases after prolonged anti-retroviral therapy and is associated with plasma LPS levels
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