Allergy/Imm Medical News about Osteoprotegerin RANK Ligand TNFRSF11B protein, human

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Urine Osteoprotegerin and Monocyte Chemoattractant Protein-1 in Lupus Nephritis
Journal of Rheumatology, 09/15/09

Kiani AN et al. – The lack of availability of urine biomarkers has hampered development of new therapies for lupus nephritis. Urine MCP–1 and OPG were both associated with measures of lupus renal disease activity. Medium or high levels of OPG were predictive of a urine protein/creatinine ratio of >= 0.5. Further study, including longitudinal assessment and correlation with concurrent renal biopsies, is necessary before this assay can be used in the routine clinic setting.

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