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Reich A et al. – Pruritus is an unpleasant sensation leading to scratching. It can be a feature of numerous skin or systemic diseases, and may also be a side–effect of various drugs. Opioids are one of the best–known medicines evoking pruritus. The pathogenesis of opioid–induced pruritus is still not fully known, but two different mechanisms have been proposed: peripheral and central. Several treatment options have been tested for opioid–induced pruritus, but none has been completely satisfactory.

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