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Targeted therapy to the IL-2R using diphtheria toxin and caspase-3 fusion proteins modulates Treg and ameliorates inflammatory colitis
European Journal of Immunology, 09/09/09
Yarkoni S et al. – The IL2–cas fusion protein is particularly relevant to inflammatory bowel disease, as direct internalization of toxic moieties overcomes multiple pathways of resistance to apoptosis of colitogenic T cells.
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Today in Gastrointestinal/Hepatic...keeping you current
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Clinical factors predicting disease course in Crohn's disease
Expert Review of Clinical Immunology, 12/17/09
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