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IL-17 and IL-22 mediate IL-20 subfamily cytokine production in cultured keratinocytes via increased IL-22 receptor expression
European Journal of Immunology, 09/29/09
Tohyama M et al. – The data indicate that increased IL–22R expression in epidermal keratinocytes contributes to the pathogenesis of psoriasis through enhancing the coordinated effects of IL–22 and IL–17, inducing the production of the IL–20 subfamily, chemokines, and growth factors.
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