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Ohkura N et al. – Adjusted deltaFEV1/year did not correlate with eNO measured during the second observation period or methacholine PC20 measured during the first observation period. On the other hand, methacholine PC20 measured during the latter period was correlated significantly with adjusted deltaFEV1/year. Persistent AHR may be a risk factor for longitudinal decline in FEV1 in asthma patients even if their asthma is stable and well controlled by inhaled corticosteroid.


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