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Intravenous immunoglobulin preparations have no direct effect on B cell proliferation and immunoglobulin production
Clinical and Experimental Immunology, 09/10/09
Heidt S et al. – The data show that IVIg is not capable of directly inhibiting key B cell responses. Direct B cell inhibition by IVIg seems therefore unlikely, implying that alteration in humoral immunity by IVIg is due to indirect effects on T cells and/or interactions with circulating antibodies and complement factors.
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