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Reciprocal effect of mesenchymal stem cell on experimental autoimmune encephalomyelitis is mediated by transforming growth factor-beta and interleukin-6
Clinical and Experimental Immunology, 09/04/09
Liu XJ et al. – The authors demonstrate that MSCs have the capacity for either stimulating or inhibiting myelin basic protein–specific T lymphocytes in a dose–dependent manner and modulate antigen–stimulated T cells to differentiate into either T helper type 17 or regulatory T cells, respectively, via pathways involving transforming growth factor–? and interleukin–6. These results may lead better utility of MSCs as a treatment for autoimmune disease.
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