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Association of tumor necrosis factor alpha, interferon gamma and interleukin 10 gene polymorphisms with peripheral neuropathy in South Indian patients with type 2 diabetes
Cytokine, 09/02/09

Kolla VK et al. – The findings indicate that the tested markers within the IFNgamma and IL–10 genes, but not the TNFalpha gene, are significantly associated with peripheral neuropathy in South Indian type 2 diabetic patients. The study shows that the ‘high–producer’ IL–10 ?1082 G/G genotype and the ‘low–producer’ IFNgamma +874 A/A genotype may be responsible for the down regulation of immune response leading to inflammation in this setting.

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